Description
Recombinant human MAST3 (1-723a.a.) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number for MAST3 is NM_015016.
MAST3 belongs to the microtubule-associated serine/threonine-protein kinase family, which is characterized by containing a serine/threonine kinase domain and a PDZ domain, and is highly expressed in brain (1). MSAT3 suppresses the degradation and promotes phosphorylation of tumor suppressor PTEN via binding to specific PDZ domains (2). MSAT3 is known to modulate the immune functions in inflammatory bowel diseases via regulating NF-kB, cell adhesion and/or migration and production of pro-inflammatory cytokines (3)